Bruker Skyscan 1276 In Vivo Micro-CT System

The Skyscan 1276 Micro-CT system

Bruker Skyscan 1276 In Vivo Micro-CT system

SkyScan 1276 is equipped with a 11-megapixel CCD camera and allows variable magnification to achieve a range of resolution, from 80 µm down to 2.8 µm. Continuous gantry rotation and step-and-shoot modes could be performed by the system with scanning cycles down to 3.9 seconds. Helical scan is available for generating distortion-free images of the sample. The flexibility to choose the desired balance between resolution, FOV, scanning method, X-ray energy and filter ensures optimal image quality for diverse research applications from small tissue samples to full rodent bodies and other materials.

Sample holder

On the other hand, the system administers a low radiation dose to the animals thus allowing multiple scans in longitudinal preclinical studies without the risk of unwanted radiation. A physiological monitoring system has been incorporated into the system for real-time detection of body movement, electrocardiography (ECG) and breathing and 4D time-resolved microtomography could be achieved.

Furthermore, a full range of software allow GPU-accelerated reconstruction, 2D/ 3D morphological and quantitative analysis, as well as surface and volume rendering.

Specifications

X-ray source: 20 – 100 kV, < 5 µm spot size at 4 W; 20W maximum power, air cooled sealed type
X-ray detector: 11 Mp (4032 x 2688) 14-bit cooled digital X-ray CCD
camera with 1x1, 2x2, 4x4 and 8x8 binning modes
Spatial resolution: 2.8 – 80 µm (depends on binning modes); 5 µm spatial resolution (10% MTF)
Scanning space: 80 mm in diameter, >300 mm in length
Sample holders and scanning cassettes: 12 mm, 20 mm, 28 mm, 40 mm, 70 mm and 73 mm (in diameter)

Important note: Users are required to

1.) Pass HSEO online test for Radiation Safety (Irradiating Apparatus)

2.) Register with HSEO through the Radiation Safety Management System as a user of SkyScan 1276

3.) Apply licence for Use of Irradiating Apparatus NOT on Human Body (For scanning LIVE animals only)

Please visit here for laser safety regulations by HSEO.

Software

SkyScan 1276 (Acquisition software)
NRecon (Reconstruction software with GPU acceleration)
Date viewer (Visualization software)
CTAn (Morphological analysis software)
CTVol (Realistic surface rendering visualization software)
CTVox (Realistic volume rendering software)

Hourly rate (Acquisition and Reconstruction)

Internal users: $150
Collaborators: $300
External users: $750

Location

Y211

Staff-in-charge

Dr. Rachel Li

Scientific Officer

Dr. Alan Leung

Scientific Officer