News

ULS Equipment Upgrade - Abberior STED Super-resolution Microcsope

The University Research Facility in Life Sciences (ULS) is pleased to announce that our Abberior STED Super-resolution Microscope has completed an upgrade in Germany and is now re-open to users. The new MATRIX detector on our STED system is an array-type avalanche photodiode detector (APD) consisting of more than 20 single-photon-counting APDs in a hexagonal arrangement. The array of APDs can simultaneously image the sample from different angles, and identify and subtract background signals in STED images using physical principles instead of image postprocessing, substantially improving the sign-to-noise ratio.   In addition, the new detector will enable researchers to perform fluorescence lifetime imaging microscopy (FLIM) in combination with STED (i.e., STED-FLIM) or confocal microscopy. These would make the STED system the most powerful and versatile fluorescence microscope the ULS has to offer.   If you have any enquiries about the STED system, please do not hesitate to contact Dr Michael Yuen.   Thank you for your attention.

New ULS Service – Next-Generation Sequencing Run Service

The University Research Facility in Life Sciences (ULS) is pleased to announce the launch of Next-Generation Sequencing (NGS) run service at PolyU.   Two Illumina NGS systems, MiSeq and NextSeq 2000, have recently been installed at the ULS. They employ the sequencing by synthesis technology to perform the run, which greatly reduces the sequencing time and maximizes data output. The 2 systems support data output from 540 Mb to 360 Gb, facilitating studies ranging from RNA sequencing, single-cell profiling to whole genome sequencing.   For more information about the NGS run service, please visit our NGS website.   If you have any inquiries about the service, please do not hesitate to contact Dr Ryan Chow or Dr Alan Leung of the ULS.   Thank you for your attention.

Mass Spectrometry Joint Seminar (ULS & UCEA): Latest mass spectrometry technologies in food, environmental and life science research (12-Sep-2023)

I am pleased to invite you to a joint seminar held by University Research Facility in Life Sciences (ULS), University Research Facility in Chemical and Environmental Analysis (UCEA),  and ThermoFisher Scientific about the latest mass spectrometry technologies in food,  environmental and life science research.    ThermoFisher Scientific is a major vendor for mass spectrometer instruments. Their trademarked "Orbitrap" mass spectrometers are well-known for their benchmarking-high mass resolution, mass accuracy and sensitivity as well as their excellent performance in various applications including proteomics, metabolomics, food analysis and environmental analysis, etc. In this seminar, experts from ThermoFisher will introduce their latest Liquid chromatography/Orbitrap mass spectrometer and Gas chromatography/Orbitrap mass spectrometers in two separated talks respectively. The details of the seminar are as follows:     Date: 12-Sept-2023 (Tuesday) Venue: Room Y715-716, Lee Shau Kee Building (Core Y) Rundown: 14:15 – 14:30: Registration 14:30 – 15:00: Seminar 1: An evolutionary Liquid chromatography/Orbitrap mass spectrometer for proteomics and native protein analysis 15:00 – 15:10: Break session 15:10 – 15:40: Seminar 2: Latest Gas chromatography/Orbitrap solutions for metabolomic, food, and environmental analysis   Due to limited seats, registration will be on first-come-first-serve basis. If you are interested in this joint seminar, please send your (1) full name,  (2) department, and (3) research group information (PI) to Dr. So Pui-Kin (pui-kin.so@polyu.edu.hk) or Dr. Tse Pui-Kam Sirius (pktse@polyu.edu.hk) by this Friday (08-Sept-2023).

New ULS Equipment - ThermoFisher Glacios 200 kV Cryo-electron Microscope

The University Research Facility in Life Sciences (ULS) is excited to announce that the ThermoFisher Glacios 200 kV Cryo-electron Microscope (Cryo-EM) is open to users. The Glacios system is equipped with the latest Falcon 4i direct electron detector, which delivers higher image quality and shorter total image acquisition time than previous models. The system is an essential piece of equipment for the whole cryo-EM workflow, as it allows researchers to verify sample quality with regard to the biochemistry and vitrification. Applications of the Glacios system include single-particle analysis (SPA), micro-electron diffraction (MicroED), and cryo-electron tomography (cryo-ET) workflows.   In addition, two sets of ThermoFisher Vitrobot Plunge-freezing Systems are also available to support sample vitrification for subsequent cryo-EM and cryo-ET workflows.   If you have any inquiries about the Glacios 200 kV Cryo-EM or the Vitrobot Plunge-freezing Systems, please do not hesitate to contact Mr Sirui Li or Dr Harvey Chan of the ULS.   Thank you for your attention.

New ULS equipment - Bruker Minispec LF90II Body Composition Analyser

The University Research Facility in Life Sciences (ULS) is pleased to announce that the Bruker Minispec LF90II Body Composition Analyser is now available for booking. It allows rapid in vivo measurements of lean tissue, body fat, and body fluid in live rodents or other samples (e.g. biopsy; food).    For training session or other enquiries, please contact Dr. Rachel Li or Dr. Eva Lau.    Thank you for your attention.  

New ULS Equipment - Bruker Biospec 70/20 USR Magnetic Resonance Imaging System

The University Research Facility in Life Sciences (ULS) is pleased to announce that the Bruker Biospec 70/20 USR Magnetic Resonance Imaging System is now open to users.   The Bruker BioSpec 70/20 USR Magnetic Resonance Imaging (MRI) System is a state-of-the-art equipment for non-invasive preclinical imaging of small animals and tissue samples. The applications of the MRI system include diffusion tensor imaging (DTI), such as fibre tracking; functional MRI (fMRI), such as brain connectivity and optogenetics; MR spectroscopy (MRS), such as detection of metabolites, amino acids, lipids; angiography and cardiac imaging.     For arranging training or for other inquiries, please contact Dr Eva Lau or Dr Rachel Li.    Thank you for your attention. 

New ULS Equipment - Zeiss Lattice Lightsheet 7 Microscope

The University Research Facility in Life Sciences (ULS) is pleased to announce that the Zeiss Lattice Lightsheet 7 (LLS7) Microscope is now open to users. The technique uses optical lattices to create ultrathin laser lightsheet to improve axial resolution and has since proved to be a power tool for live imaging. The LLS7 system has a specially designed inverted configuration that allows researchers to use common sample carriers and is equipped with 2 scientific-grade CMOS cameras for simultaneous dual-channel imaging at speed up to 3 volume scans per second.   To introduce the major functions and applications of the LLS7 system, the ULS is going to hold a number of demonstration sessions on 9th August, 2023.  Online registration is now open until 3rd August, 2023.   Please contact Dr Michael Yuen for enquiries of the equipment or the demonstration.   Thank you for your attention.

New ULS Equipment - ThermoFisher Talos L120C Transmission Electron Microscope

The University Research Facility in Life Sciences (ULS) is pleased to announce that the ThermoFisher Talos L120C Transmission Electron Microscope (TEM) is now available for booking. The new system has been installed in the ULS Cryo-EM Centre, and is mainly used for sample screening and data collection using negatively stained biological specimens. The enhanced contrast of negative stain EM allows preliminary examination of relatively small biological samples with sizes under 30 nm, such as protein particles. The Talos L120C will enable researchers to acquire high-quality images with simple and intuitive image acquisition software.   If you have any queries about the Talos L120C TEM System, please do not hesitate to contact Mr Sirui Li or Dr Michael Yuen of the ULS.   Thank you for your attention.  

NEW ULS Equipment - Labfreez FD-12R-80C Freeze Dryer

The University Research Facility in Life Sciences (ULS) is pleased to announce that the Labfreez FD-12R-80C Freeze Dryer is now available for booking. It is equipped with a -80oC dual cascade refrigeration condenser, providing maximum performance for freeze drying of biological sample, food and pharmaceuticals. Please contact Dr. Ryan CHOW for enquiries of the equipment or training arrangement. Thank you for your attention.

New ULS Equipment - Nikon AX R MP Upright Multiphoton Microscope

The University Research Facility in Life Sciences (ULS) has been supported by the Collaborative Research Fund (CRF) 2021/22 to acquire a Nikon AX R MP Upright Multiphoton (MP) Microscope.  The system is equipped with a dual-output pulsed laser for simultaneous multi-channel MP imaging and/or photostimulation, and supports high-speed intravital imaging using small animals. The system has been installed at the newly built Animal Imaging Centre (AIC) on Podium of Block Y and is now open for booking.   To introduce the major functions and applications of the new system, the ULS is going to hold a number of demonstration sessions on 5th and 12th July.  Online registration is now open until 2nd July.   Please contact Dr Michael Yuen for enquiries of the equipment or the demonstration.   Thank you for your attention.